منابع مشابه
Exclusion mapping.
The basis for using information against linkage to some loci to support linkage to other loci is discussed and data on cystic fibrosis available up to late July 1985 used as an example.
متن کاملMapping and exclusion mapping of genomic imprinting effects in mouse F2 families.
Parent-of-origin effects were mapped by multimarker regression analysis in a cross between a high body weight selected line (DU6) and a control line (DUKs). The difference between F(2) progeny being heterozygous Qq and qQ (first allele is paternally derived) for grandpaternal Q and grandmaternal q alleles was genome-wide significant for the traits liver weight and spleen weight with a paternal ...
متن کاملInclusion-exclusion meets exclusion
When evaluating the inclusion-exclusion expansion N0 −N(1) −N(2) − · · ·+N(1, 2) +N(1, 3) + · · · many of the terms N(· · ·) may turn out to be zero, and hence should be discarded beforehand. Often this can be done.
متن کاملFibulin-2: genetic mapping and exclusion as a candidate gene in Marfan syndrome type 2.
Fibulin-2 (FBLN2) is a new extracellular matrix protein that has been considered a candidate gene for Marfan syndrome type 2 (locus MFS2) based on chromosomal colocation at 3p24.2-p25 and disease phenotype. In the absence of polymorphic markers reported for FBLN2, direct sequencing of the gene was performed and two intragenic polymorphisms were identified. Linkage was excluded between FBLN2 and...
متن کاملExclusion mapping of the hereditary dentatorubropallidoluysian atrophy gene from the Huntington's disease locus.
Hereditary dentatorubropallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder. Clinical and genetic findings in hereditary DRPLA are very similar to those of Huntington's disease (HD). However, it can be differentiated from HD by the pathological findings of dentatorubral and pallidoluysian atrophies and by a lack of prominent atrophy of the striatum at necropsy. The...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1987
ISSN: 1468-6244
DOI: 10.1136/jmg.24.9.539